The 8th International Conference on Biomedical Engineering and Biotechnology (ICBEB 2019)
October 22-25, 2019, Seoul, Republic of Korea
Invited Speaker--Dr. Josef Jampílek

1Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia;
2Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University Olomouc, Czech Republic

Josef Jampilek completed his Ph.D. degree in Medicinal Chemistry at the Faculty of Pharmacy of the Charles University (Czech Republic) in 2004. In 2004-2011, he worked in expert and managerial posts in the R&D Division of the pharmaceutical company Zentiva (Czech Republic). Prof. Jampilek deepened his professional knowledge at the Medicinal Chemistry Institute of the Heidelberg University (Germany) and at multiple specialized courses. In 2009, he became an Associate Professor of Medicinal Chemistry at the Faculty of Pharmacy of the University of Veterinary and Pharmaceutical Sciences Brno (Czech Republic). In 2017, he became a Full Professor of Medicinal Chemistry at the Faculty of Pharmacy of the Comenius University (Slovakia). He is an author/co-author of more than 30 patents/patent applications, more than 180 peer-reviewed scientific publications, 7 university textbooks, 20 chapters in monographs, and many invited lectures at international conferences and workshops. He also received several awards for his scientific results, e.g., from Aventis, Elsevier, Willey, Sanofi and FDA. The research interests of Prof. Jampilek include design, synthesis, and structure-activity relationships of heterocyclic compounds as anti-infectious, antiproliferative and anti-inflammatory agents as well as photosynthesis inhibitors. He is also interested in ADME and drug bioavailability.

Speech Title: Biological effects of compounds based on cinnamic acid scaffold

Abstract: One of the strategies of the development of new drugs is based on the concepts of privileged structures, polypharmacology and multifactorial diseases [1,2]. Cinnamic acids can be considered as one of privileged multi-target structures. Cinnamic acids and other hydroxy-, amino-, halogene- or phenyl-substituted derivatives of cinnamic acids have been widely investigated due to their significant and varied biological effects. The spectrum of their biological activities include hepatoprotective, antioxidant, anti-inflammatory, antidiabetic, anticancer, antiviral, antibacterial and antifungal effects. Derivatives of cinnamic acids are also used as agricultural fungicides [3,4]. This contribution is focused on biologically active agents based on the cinnamonic scaffold and the influence of various substituents on intensification of different biological effects.

1. Ramsay, R.R.; Popovic-Nikolic, M.R.; Nikolic, K.; Uliassi, E.; Bolognesi, M.L. Clin. Transl. Med. 2018, 7, 3.
2. Ray, P.C.; Kiczun, M.; Huggett, M.; Lim, A.; Prati, F.; Gilbert, I.H.; Wyatt, P.G. Drug Discov. Today 2017, 22, 43-56.
3. Dolab, J.G.; Lima, B.; Spaczynska, E.; Kos, J.; Cano, N.H.; Feresin, G.; Tapia, A.; Garibotto, F.; Petenatti, E.; Olivella, M.; Musiol, R.; Jampilek, J.; Enriz, R.D. Molecules 2018, 23, 1187.
4. Pospisilova, S.; Kos, J.; Michnova, H.; Kapustikova, I.; Strharsky, T.; Oravec, M.; Moricz, A.M.; Bakonyi, J.; Kauerova, T.; Kollar, P.; Cizek, A.; Jampilek, J. Int. J. Mol. Sci. 2018, 19, 2318

Keywords: cinnamic acids, rational design, antimicrobials, anti-inflammatory agents
The 8th International Conference on Biomedical Engineering and Biotechnology
Conference Secretaries: Ms. Linda Li, Ms. Annie Zhu, Ms. Cassie Cheng
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