Biography: Dr. William Cho primarily focused on cancer studies with the aim of identifying biomarkers for cancer diagnosis, treatment prediction, and prognosis. As a seasoned researcher, I have employed various disciplines such as molecular biology, proteomics, genomics, immunology, and bioinformatics to conduct cancer research. I am proud to have contributed over 600 peer-reviewed papers to reputable journals including Lancet, Lancet Oncology, Annals of Oncology, Advanced Science, Nature Communications, Cancer Communications, PNAS, Science Advances, Journal of the National Cancer Institute, Journal of Extracellular Vesicles, Clinical Cancer Research, Molecular Cancer, and Theranostics, among others. These publications cover a wide range of topics including cancer biomarkers, non-coding RNAs, extracellular vesicles, drug repurposing and Chinese medicine. Additionally, I am an editor of over two dozen books, including "MicroRNAs in Cancer Translational Research", "An Omics Perspective on Cancer Research", "Supportive Cancer Care with Chinese Medicine", "Drug Repurposing in Cancer Therapy: Approaches and Applications", and “Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal” to name a few.
Dr. Cho published papers have garnered more than 30,000 citations and Dr Cho is being listed in the top 2% most influential scientists in the world.
Recently, I’m also listed in the Highly Cited Researchers in 2023 by Clarivate.

Abstract: In the last decades, advances in bone tissue engineering mainly based on osteoinduction and stem cell research. Only recently, new efforts focused on the micro- and nanoarchitecture needed to improve and accelerate bone regeneration. By the use of additive manufacturing, libraries of bone substitutes were produced and tested for the optimal pore size, filament dimension, or lightweight microarchitecture to treat bone defects and promote bone augmentation. To that end, we produced pore-based, filament-based and triply periodic lightweight-based scaffolds and tested them in a cranial defect and a bone augmentation model in rabbits.
For the production of scaffolds, we applied the CeraFab 7500 from Lithoz, a lithography-based additive manufacturing machine and studied tri-calcium phosphate- based and hydroxyapatite-based scaffolds. As in vivo test model, we used a calvarial defect and a bone augmentation model in rabbits. Histomorphometry and microCT analysis showed that optimal pore and filament designs for osteoconduction differ from the ones for bone augmentation. For triply periodic minimal surface lightweight microarchitectures, a single gyroid- and diamond-microarchitecture performs well in bone augmentation and cranial defect models. Small adjustments of filament-based microarchitectures orchestrate cell differentiation towards osteoblasts and facilitates angiogenesis.
In essence, we have identified the optimal triply periodic lightweight, pore-based and filament-based microarchitecture for bone augmentation purposes needed for the placement of dental implants and for cranial defects. We learned that the optimal pore-based and filament-based microarchitecture for bone augmentations differs from the best for the treatment of defects. Moreover, we saw that additive manufacturing appears as a promising tool for the production of personalized bone substitutes to be used in cranio-maxillofacial surgery, dentistry, and orthopaedics.

Keywords: Additive manufacturing, Bone substitute; Osteoconduction; bone augmentation Microarchitecture.

Biography: Franz Weber graduated from the University Konstanz (Germany) with a PhD in Biology/Muscle Biochemistry. He completed a 3-year postdoctoral training on muscle cell biology at Cornell University Medical College in New York City and served as a lecturer in the Department of Cell Biology and Anatomy. He spent the following two years at Biochemistry of the ETH Zurich working on the lipid uptake from the small intestine. In 1995, he joined the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Zurich. Beside his obligations at the University of Zurich, he became Director of the European Technical Center of Inion Ltd in Cambridge (UK) in 2005 and occupied this position until 2009. His research encompasses additive manufacturing, bone substitutes, osteoconduction, bone morphogenetic proteins, delivery systems, epigenetics, bone and pulp tissue engineering. Franz E. Weber has authored 137 peer-reviewed research articles published in international journals amounting to more than 7234 citations, 16 patents, several review articles, book chapters, and an h-index of 40. He is member of TERMIS (Tissue Engineering international & Regenerative Medicine Society), IADR (International Association for Dental Research), DKG (German Ceramic Society), ACerS (The American Ceramic Society), and SSB+RM (Swiss Society for Biomaterials and Regenerative Medicine).
He is currently appointed as Professor of Craniofacial and Oral Biotechnology at the Center of Dental Medicine, member of the Medical and the Science Faculty of the University of Zurich.

Biography: Dr. Wencheng Zhang is a current research associate professor at Shanghai East Hospital Affiliated to Tongji University. He went to the Northwest Agriculture and Forestry University for his undergraduate with a major of bioscience from 2003 to 2007. Then, he got his PhD in regenerative medicine from the Academy of Military Medicine Science in 2012. He went to the University of North Carolina at Chapel Hill for his postdoctoral training with Prof. Lola M. Reid for studying the endodermal stem cells and developing the patch grafting strategy. And later, he worked as a research associate in Prof. Reid`s and Prof. Jian Liu`s labs, respectively, for investigating the biological effects of heparin sulfate glycosaminoglycans. At current, Dr. Zhang`s research has been supported by four national or provincial grants. He has 20 publications on the journal such as Cell Stem Cell, Journal of Hepatology, Hepatology, and Biomaterials, etc. with a total impact factor 178.838; total citation on Google Scholar 208; he also is an inventor on 9 major patents including being a lead inventor on patents on patch grafting strategies. His current research interests include hepatic-maturation of stem cells post-grafting, as well as glycosaminoglycans in stem cell expansion and cell fate determination.

Biography: Dr. Xufeng Yao works as a professor, doctoral supervisor, vice dean of the school of medical imaging, Shanghai University of Medicine and Health Sciences, China. Once, he received his bachelor in medical imaging from Shandong First Medical University, and graduated from Fudan University for his PhD in biomedical engineering, and was a post-doctoral student in optical engineering at University of Shanghai for Science and Technology, China. He was also appointed as a permanent member of the committee of life electronics branch of China institute of electronics society. His current research interest focuses on artificial intelligence in imaging and omics for medicine. He won about 10 funds of national science foundation of China, Shanghai natural science foundation, China postdoctoral foundation, innovation fund of Shanghai Education Commission, etc. Recently, he has published more than 40 academic papers and reviewed for some SCI journals and international conferences. Till now, he has trained above 20 graduate students.